

Screening for keratoconus early signs in planning keratorefractive surgery
https://doi.org/10.33791/2222-4408-2022-4-7-12
Abstract
Clinical relevance. Keratoconus (KC) without clinical manifestations (subclinical stage) occurs in patients with ametropia periodically. Before refractive surgery, in time detection of early signs of this pathology is important as KC is a contraindication to its application.
Purpose: to analyze and compare informative value of the Pentacam HR projection-based tomograph, the TOMEY TMS-4 reflecting-based corneal topographer and the CASIA-2 optical coherent tomograph to identify early signs of KC before refractive laser surgery.
Materials and methods. A prospective study of cornea morphometric parameters in 81 patients (162 eyes) who applied to the Cheboksary branch of the Intersectoral Scientific and Technical Complex “Eye Microsurgery” was performed in order to resolve the issue of refractive surgery possibility with various types of ametropia during the second half of 2020 year. In addition to the generally accepted ones, examinations were carried out using the above-mentioned devices. Age of the patients ranged from 18 to 38 years old (on average 25 ± 5). The sample consisted of 33 (40.81%) men and 48 (59.19%) women.
Results. According to the TOMEY TMS-4 reflecting-based corneal topographer, suspicion of KC was detected in 6 patients (11 eyes) that amounted to 6.79% of all examined patients. The Pentacam HR projection-based tomograph revealed suspicion of KC in 9 patients (18 eyes or 11.11% of all examined patients). While using the CASIA-2 optical coherent tomograph, suspicion of KC was detected by ESI (Ectasia Screening Index) Anterior in 6 patients (11 eyes), and by ESI Posterior in 7 patients (14 eyes) that amounted to 6.79 and 8.64% of all examined patients respectively.
Conclusion. The data obtained during the study showed the greatest informativity and efficiency of the Pentacam tomograph in screening for early signs of KC.
About the Authors
M.-A. B. ErgashevRussian Federation
Mukhammad-Ali B. Ergashev, Resident
27, Mikhail Sespel Str., Cheboksary, 428018
N. A. Pozdeeva
Russian Federation
Nadezhda A. Pozdeeva, Dr. Sci. (Med.), Professor of the Institute for the Postgraduate Education of Doctors; Director of the Cheboksary branch of the the S. Fyodorov Eye Microsurgery Federal State Institution
27, Mikhail Sespel Str., Cheboksary, 428018
10, Traktorostroiteley Ave., Cheboksary, 428028
N. A. Maslova
Russian Federation
Nadezhda A. Maslova, Cand. Sci. (Med.), Ophthalmologist of the Highest qualification Category, Head of the First Laser Department (Bottom)
10, Traktorostroiteley Ave., Cheboksary, 428028
S. M. Pikusova
Russian Federation
Svetlana M. Pikusova, Ophthalmologist of the Laser Refractive Department and Junior Researcher
10, Traktorostroiteley Ave., Cheboksary, 428028
References
1. Randleman J.B., Woodward M., Lynn M.J., Stulting R.D. Risk assessment for ectasia after corneal refractive surgery. Ophthalmology. 2008;115:37–50. https://doi.org/10.1016/j.ophtha.2007.03.073
2. Binder P.S. Analysis of ectasia after laser in situ keratomileusis: risk factors. Cataract Refract Surg. 2007;33(9):1530–1538. https://doi.org/10.1016/j.jcrs.2007.04.043
3. Pozdeeva N.A., Maslova N.A., Zotov V.V. et al. Modern methods of diagnosis and surgical treatment of keratoconus. N.P. Pashtaev, ed. Moscow: Cheboksary branch of the S. Fyodo rov Eye Microsurgery Federal State Institution, 2017:16–18. (In Russ.)
4. Bikbov M.M., Bikbova G.M. Corneal ectasia. Moscow: Publishing house “Ophthalmology”, 2011:11, 12, 21–28, 30–32. (In Russ.)
5. Ruben M. Treatment of keratoconus. Ophthalmol Optician. 1978;18(3):64–71.
6. Kasparova E.A. Early diagnosis, laser and surgical treatment of keratoconus: abstract dis. D-r Sci. (Med.). Moscow, 2003:27. (In Russ.)
7. Ambrósio R.Jr., Caiado A.L., Guerra F.P. Novel pachymetric parameters based on corneal tomography for the diagnosis of keratocorefractive surgery. J Refract Surg. 2011;27(10):753. https://doi.org/10.3928/1081597x-20110721-01
8. Belin M.W., Ambrósio R. Scheimpflug-Bildgebung bei Keratokonus und ektatischen Erkrankungen. Indisches J Ophthalmol. 2013;61:401–406. https://doi.org/10.4103/0301-4738.116059
9. Maeda N., Klyce S.D., Smolek M.K., Thompson H.W. Automated keratoconus screening with corneal topography analysis. Invest Ophthalm. Vis. Sci. 1994;35:2749–2757. https://doi.org/10.1097/00003226-199301000-00029
10. Grigoryan A.V. Keratotopographic indexes in the diagnosis and classification of keratoconus. Dis. ... Cand. Sci. (Med.). Moscow, 2019:201. (In Russ.)
11. Gomes J.A., Tan D., Rapuano C.J. et al. Global consensus on keratoconus and ecstatic diseases. Group of Panelists for the Global Delphi Panel of Keratoconus and Ectatic Diseases. Cornea. 2015;34(4):359–369. https://doi.org/10.1097/ico.0000000000000408
12. Saad A., Gatinel D. Topographic and tomographic properties of forme fruste keratoconus corneas. Invest Ophthalmol Vis Sci. 2010;51(11):5546–5555. https://doi.org/10.1167/iovs.10-5369
13. Correia F.F., Ramos I., Lopes B. et al. Topometric and Tomographic Indices for the Diagnosis of Keratoconus. International Journal of Keratoconus and Ectatic Corneal Diseases. 2012;1(2):92–99. https://doi.org/10.5005/jp-journals-10025-1018
14. Belin M.W., Ambrósio R. Scheimpflug imaging for keratoconus and ectatic disease. Indian Journal of Ophthalmology. 2013;61(8):401–406. https://doi.org/10.4103/0301-4738.116059
15. Salomao M., Hoffing-Lima A., Lopes B. et al. Recent developments in keratoconus diagnosis. Expert Rev. Ophthalmol. 2018;13:329–370. https://doi.org/10.1080/17469899.2018.1555036
16. Wilson S.E., Ambrosio R. Computerized corneal topography and its importance to wavefront technology. Cornea. 2001;20:441– 495. https://doi.org/10.1097/00003226-200107000-00001
17. Shetty R., Rao H., Khamar P. et al. Keratoconus screening indices and their diagnostic ability to distinguish normal from ectatic corneas. American Journal of Ophthalmology. 2017;181:140–148. https://doi.org/10.1016/j.ajo.2017.06.031
18. Vinciguerra R., Ambrósio R., Elsheikh A. et al. Detection of keratoconus with a new biomechanical index. Journal of Refractive Surgery. 2016;32(12):803–810. https://doi.org/10.3928/1081597x-20160629-01
19. Semenova A.L. Clinical and laboratory diagnostics of the early stages of keratoconus. Dis. ...Cand. Sci. (Med.). Moscow, 2009:127. (In Russ.)
Review
For citations:
Ergashev M.B., Pozdeeva N.A., Maslova N.A., Pikusova S.M. Screening for keratoconus early signs in planning keratorefractive surgery. The EYE GLAZ. 2022;24(4):7-12. (In Russ.) https://doi.org/10.33791/2222-4408-2022-4-7-12