Preview

The EYE GLAZ

Advanced search
Open Access Open Access  Restricted Access Subscription or Fee Access

Myopia progression in young adults: a literature review

https://doi.org/10.33791/2222-4408-2026-2-149-154

Abstract

Background. Myopia onset and progression are generally associated with school age; however, axial elongation and myopic progression have also been documented in some individuals older than 18 years. Data on myopia in young adults remain limited. Important unresolved issues include the age at which myopia stabilizes after adolescence, the occurrence of incident myopia in young adulthood, the rate of progression, and the identification of risk factors and effective control strategies. Purpose: To synthesize the current evidence on the onset and progression of myopia in adults aged 18 to 40 years and to identify gaps in understanding of risk factors and the effectiveness of myopia control interventions. Materials and methods. A literature review and analysis of original studies indexed in PubMed, MEDLINE, and eLibrary and published between 1987 and 2025 was performed. Eighty-nine publications met the initial inclusion criteria: original studies and reviews; participant age 18–40 years; and quantitative data on changes in refractive error and/or axial length. Of these, 46 studies were included in the final review. Results. Over the past decade, growing evidence has shown that myopia may continue to progress in adulthood, challenging the widely held view that it stabilizes in late adolescence. Clinically meaningful progression can reach approximately 1.00 D between 20 and 30 years of age. Although several myopia control interventions have demonstrated efficacy in children, there is currently no convincing evidence supporting their use in young adults. Factors potentially associated with myopia progression in this age group include genetic predisposition, demographic characteristics, and environmental exposures. Conclusion. Myopia progression in young adults is clinically relevant, but the timing of stabilization and the underlying risk factors remain poorly understood. Further studies are needed to identify structural and biometric predictors of axial elongation and to evaluate the effectiveness of myopia control strategies in young adults.

About the Authors

N. S. Grigor’eva
Lomonosov Moscow State University
Russian Federation

Natal’ya S. Grigor’eva, Resident, Department of Ophthalmology, Faculty of Fundamental Medicine

27/1 Lomonosovsky Ave., Moscow, 119991



A. N. Stulova
Lomonosov Moscow State University
Russian Federation

Anna N. Stulova, Cand. Sci. (Med.), Assistant, Department of Ophthalmology, Faculty of Fundamental Medicine

27/1 Lomonosovsky Ave., Moscow, 119991



V. S. Akopyan
Lomonosov Moscow State University
Russian Federation

Vladimir S. Akopyan, Dr. Sci. (Med.), Professor, Head of the Department of Ophthalmology, Faculty of Fundamental Medicine

27/1 Lomonosovsky Ave., Moscow, 119991



N. S. Semenova
Lomonosov Moscow State University
Russian Federation

Nataliya S. Semenova, Cand. Sci. (Med.), Associate Professor, Department of Ophthalmology, Faculty of Fundamental Medicine

27/1 Lomonosovsky Ave., Moscow, 119991



References

1. Grosvenor T. A review and a suggested classification system for myopia on the basis of age-related prevalence and age of onset. Am J Optom Physiol Opt. 1987;64:545–554.

2. National Research Council. Working Group on Myopia Prevalence and Progression. Myopia: Prevalence and Progression. Washington, D.C.: National Academy Press, 1989. URL: https://www.ncbi.nlm.nih.gov/books/NBK235062/pdf/Bookshelf_NBK235062.pdf

3. Moore M, Lingham G, Flitcroft DI, Loughman J. Patterns of Myopia Progression in European Adults. Ophthalmol Sci. 2025;5(3):100713. doi: 10.1016/j.xops.2025.100713

4. COMET Group. Myopia stabilization and associated factors among participants in the Correction of Myopia Evaluation Trial (COMET). Invest Ophthalmol Vis Sci. 2013;54(13):7871– 7884. doi: 10.1167/iovs.13-12403

5. Brennan NA, Cheng X, Bullimore MA. Adult Myopia Progression. Invest Ophthalmol Vis Sci. 2024;65(13):49. doi: 10.1167/iovs.65.13.49

6. Lee SS, Lingham G, Sanfilippo PG, Hammond CJ, Saw SM, Guggenheim JA, Yazar S, Mackey DA. Incidence and Progression of Myopia in Early Adulthood. JAMA Ophthalmol. 2022;140(2):162–169. doi: 10.1001/jamaophthalmol.2021.5067

7. Bullimore MA, Jones LA, Moeschberger ML, Zadnik K, Payor RE. A retrospective study of myopia progression in adult contact lens wearers. Invest Ophthalmol Vis Sci. 2002;43(7):2110– 2113.

8. Brennan NA, Cheng X, Bullimore MA. Adult Myopia Progression. Invest Ophthalmol Vis Sci. 2024;65(13):49. doi: 10.1167/iovs.65.13.49

9. Ducloux A, Marillet S, Ingrand P, Bullimore MA, Bourne RRA, Leveziel N. Progression of myopia in teenagers and adults: a nationwide longitudinal study of a prevalent cohort. Br J Ophthalmol. 2023;107(5):644-649. doi: 10.1136/bjophthalmol-2021-319568

10. Midelfart A, Kinge B, Midelfart S, Lydersen S. Prevalence of refractive errors in young and middle-aged adults in Norway. Acta Ophthalmol Scand. 2002;80(5):501–505. doi: 10.1034/j.1600-0420.2002.800508.x

11. Brennan NA, Shamp W, Maynes E, Cheng X, Bullimore MA. Infl uence of age and race on axial elongation in myopic children: A systematic review and meta-regression. Optom Vis Sci. 2024;101(8):497–507. doi: 10.1097/OPX.0000000000002176

12. Morgan IG, Iribarren R, Fotouhi A, Grzybowski A. Cycloplegic refraction is the gold standard for epidemiological studies. Acta Ophthalmol. 2015;93(6):581–585. doi: 10.1111/aos.12642

13. Dirani M, Shekar SN, Baird PN. Adult-onset myopia: the Genes in Myopia (GEM) twin study. Invest Ophthalmol Vis Sci. 2008;49(8):3324–3327. doi: 10.1167/iovs.07-1498

14. Tideman JW, Fan Q, Polling JR, Guo X, Yazar S, Khawaja A, Höhn R, Lu Y, Jaddoe VW, Yamashiro K, Yoshikawa M, Gerhold-Ay A, Nickels S, Zeller T, He M, Boutin T, Bencic G, Vitart V, Mackey DA, Foster PJ, MacGregor S, Williams C, Saw SM, Guggenheim JA, Klaver CC; CREAM Consortium. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Genet Epidemiol. 2016;40(8):756–766. doi: 10.1002/gepi.21999

15. Iribarren R, Iribarren G, Castagnola MM, Balsa A, Cerrella MR, Armesto A, Fornaciari A, Pförtner T. Family history and reading habits in adult-onset myopia. Curr Eye Res. 2002;25(5):309–315. doi: 10.1076/ceyr.25.5.309.13494

16. Koomson NY, Kobia-Acquah E, Abdul-Kabir M, Aderonke UM, Kwaw RJ, Arkhurst EE. Relationship between peripheral refraction, axial lengths and parental myopia of young adult myopes. J Optom. 2022;15(2):122–128. doi: 10.1016/j.optom.2020.10.007

17. Lin LL, Shih YF, Lee YC, Hung PT, Hou PK. Changes in ocular refraction and its components among medical students a 5-year longitudinal study. Optom Vis Sci. 1996;73(7):495–498. doi: 10.1097/00006324-199607000-00007

18. Dutheil F, Oueslati T, Delamarre L, Castanon J, Maurin C, Chiambaretta F, Baker JS, Ugbolue UC, Zak M, Lakbar I, Pereira B, Navel V. Myopia and Near Work: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2023;20(1):875. doi: 10.3390/ijerph20010875

19. Loman J, Quinn GE, Kamoun L, Ying GS, Maguire MG, Hudesman D, Stone RA. Darkness and near work: myopia and its progression in third-year law students. Ophthalmology. 2002;109(5):1032–1038. doi: 10.1016/s0161-6420(02)01012-6

20. Kinge B, Midelfart A. Refractive changes among Norwegian university students a three-year longitudinal study. Acta Ophthalmol Scand. 1999;77(3):302–305. doi: 10.1034/j.1600-0420.1999.770311.x

21. Liu M, Wang Y, Li H, Zhao Y, Ma M, Xu S, Wei X, Xu R, Tian R, Zhou X, Wu H. Differences in choroidal responses to near work between myopic children and young adults. Eye Vis (Lond). 2024;11(1):12. doi: 10.1186/s40662-024-00382-5

22. Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29(2):144–168. doi: 10.1016/j.preteyeres.2009.12.002

23. Lee SS, Mackey DA. Prevalence and Risk Factors of Myopia in Young Adults: Review of Findings From the Raine Study. Front Public Health. 2022;10:861044. doi: 10.3389/fpubh.2022.861044

24. McKnight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, Pennell CE, McAllister IL, Young TL, Coroneo MT, Mackey DA. Myopia in young adults is inversely related to an objective marker of ocular sun exposure: the Western Australian Raine cohort study. Am J Ophthalmol. 2014;158(5):1079–1085. doi: 10.1016/j.ajo.2014.07.033

25. Read SA, Pieterse EC, Alonso-Caneiro D, Bormann R, Hong S, Lo CH, Richer R, Syed A, Tran L. Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults. Sci Rep. 2018;8(1):8200. doi: 10.1038/s41598-018-26635-7

26. Brainard GC, Morgan WW. Light-induced stimulation of retinal dopamine: a dose-response relationship. Brain Res. 1987;424(1):199–203. doi:10.1016/0006-8993(87)91211-x

27. Hoseini-Yazdi H, Read SA, Collins MJ, Bahmani H, Ellrich J, Schilling T. Increase in choroidal thickness after blue light stimulation of the blind spot in young adults. Bioelectron Med. 2024;10(1):13. doi: 10.1186/s42234-024-00146-5

28. Amorim-de-Sousa A, Schilling T, Fernandes P, Seshadri Y, Bahmani H, González-Méijome JM. Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes. Sci Rep. 2021;11(1):9273. doi: 10.1038/s41598-021-88459-2

29. Zhang RH, Yang Q, Dong L, Li YF, Zhou WD, Wu HT, Li HY, Shao L, Zhang C, Wang YX, Wei WB. Association between vitamin D and myopia in adolescents and young adults: Evidence of national cross-sectional study. Eur J Ophthalmol. 2023;33(5):1883–1891. doi: 10.1177/11206721231161498

30. Chen Z, Xue F, Zhou J, Qu X, Zhou X. Effects of Orthokeratology on Choroidal Thickness and Axial Length. Optom Vis Sci. 2016;93(9):1064–1071. doi: 10.1097/OPX.0000000000000894

31. Lee JH, Hong IH, Lee TY, Han JR, Jeon GS. Choroidal Thickness Changes after Orthokeratology Lens Wearing in Young Adults with Myopia. Ophthalmic Res. 2021;64(1):121–127. doi: 10.1159/000510715

32. Bullimore MA, Richdale K. Myopia Control 2020: Where are we and where are we heading? Ophthalmic Physiol Opt. 2020;40(3):254–270. doi: 10.1111/opo.12686

33. Gifford KL, Richdale K, Kang P, Aller TA, Lam CS, Liu YM, Michaud L, Mulder J, Orr JB, Rose KA, Saunders KJ, Seidel D, Tideman JWL, Sankaridurg P. IMI – Clinical Management Guidelines Report. Invest Ophthalmol Vis Sci. 2019;60(3):M184–M203. doi: 10.1167/iovs.18-25977

34. Donovan L, Sankaridurg P, Ho A, Naduvilath T, Smith EL 3rd, Holden BA. Myopia progression rates in urban children wearing single-vision spectacles. Optom Vis Sci. 2012;89(1):27–32. doi: 10.1097/OPX.0b013e3182357f79

35. Lam CSY, Tang WC, Zhang HY, Lee PH, Tse DYY, Qi H, Vlasak N, To CH. Long-term myopia control effect and safety in children wearing DIMS spectacle lenses for 6 years. Sci Rep. 2023;13(1):5475. doi: 10.1038/s41598-023-32700-7

36. Bao J, Huang Y, Li X, Yang A, Zhou F, Wu J, Wang C, Li Y, Lim EW, Spiegel DP, Drobe B, Chen H. Spectacle Lenses With Aspherical Lenslets for Myopia Control vs Single-Vision Spectacle Lenses: A Randomized Clinical Trial. JAMA Ophthalmol. 2022;140(5):472–478. doi: 10.1001/jamaophthalmol.2022.0401

37. Gao Y, Lim EW, Drobe B. Impact of myopia control spectacle lenses with highly aspherical lenslets on peripheral visual acuity and central visual acuity with peripheral gaze. Ophthalmic Physiol Opt. 2023;43(3):566–571. doi: 10.1111/opo.13127

38. Chamberlain P, Bradley A, Arumugam B, Hammond D, McNally J, Logan NS, Jones D, Ngo C, Peixoto-de-Matos SC, Hunt C, Young G. Long-term Effect of Dual-focus Contact Lenses on Myopia Progression in Children: A 6-year Multicenter Clinical Trial. Optom Vis Sci. 2022;99(3):204–212. doi: 10.1097/OPX.0000000000001873

39. Kang P, McAlinden C, Wildsoet CF. Effects of multifocal soft contact lenses used to slow myopia progression on quality of vision in young adults. Acta Ophthalmol. 2017;95(1):e43–e53. doi: 10.1111/aos.13173

40. Sun Y, Xu F, Zhang T, Liu M, Wang D, Chen Y, Liu Q. Orthokeratology to control myopia progression: a meta-analysis. PLoS One. 2015 Apr 9;10(4):e0124535. doi: 10.1371/journal.pone.0124535. Erratum in: PLoS One. 2015;10(6):e0130646. doi: 10.1371/journal.pone.0130646

41. González-Méijome JM, Carracedo G, Lopes-Ferreira D, Faria-Ribeiro MA, Peixoto-de-Matos SC, Queirós A. Stabilization in early adult-onset myopia with corneal refractive therapy. Cont Lens Anterior Eye. 2016;39(1):72–77. doi: 10.1016/j.clae.2015.06.009

42. Gifford KL, Gifford P, Hendicott PL, Schmid KL. Zone of Clear Single Binocular Vision in Myopic Orthokeratology. Eye Contact Lens. 2020;46(2):82–90. doi: 10.1097/ICL.0000000000000614

43. Ren Q, Yang B, Liu L, Cho P. Orthokeratology in adults and effect on quality of life. Cont Lens Anterior Eye. 2023;46(3):101824. doi: 10.1016/j.clae.2023.101824

44. Lawrenson JG, Shah R, Huntjens B, Downie LE, Virgili G, Dhakal R, Verkicharla PK, Li D, Mavi S, Kernohan A, Li T, Walline JJ. Interventions for myopia control in children: a living systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023;2(2):CD014758. doi: 10.1002/14651858.CD014758.pub2. Update in: Cochrane Database Syst Rev. 2025;2:CD014758. doi: 10.1002/14651858.CD014758.pub3

45. Yam JC, Zhang XJ, Zhang Y, Wang YM, Tang SM, Li FF, Kam KW, Ko ST, Yip BHK, Young AL, Tham CC, Chen LJ, Pang CP. Three-Year Clinical Trial of Low-Concentration Atropine for Myopia Progression (LAMP) Study: Continued Versus Washout: Phase 3 Report. Ophthalmology. 2022;129(3):308–321. doi: 10.1016/j.ophtha.2021.10.002

46. Kaymak H, Fricke A, Mauritz Y, Löwinger A, Klabe K, Breyer D, Lagenbucher A, Seitz B, Schaeffel F. Short-term effects of low-concentration atropine eye drops on pupil size and accommodation in young adult subjects. Graefes Arch Clin Exp Ophthalmol. 2018;256(11):2211–2217. doi: 10.1007/s00417-018-4112-8


Review

For citations:


Grigor’eva N.S., Stulova A.N., Akopyan V.S., Semenova N.S. Myopia progression in young adults: a literature review. The EYE GLAZ. 2026;28(2):149-154. (In Russ.) https://doi.org/10.33791/2222-4408-2026-2-149-154

Views: 72

JATS XML

ISSN 2222-4408 (Print)
ISSN 2686-8083 (Online)