glazmagThe EYE ГЛАЗThe EYE GLAZ2222-44082686-8083Академия медицинской оптики и оптометрии10.33791/2222-4408-2026-1-47-55glazmag-779Research ArticleОБЗОРНЫЕ СТАТЬИREVIEWSОценка структурных характеристик хориоидеи с помощью оптической когерентной томографииAssessment of choroidal structural characteristics using optical coherence tomographyХозяеваА. А.KhozyaevaA. A.

Хозяева Анастасия Александровна, врач-ординатор кафедры офтальмологии факультета фундаментальной медицины 

119991, г. Москва, Ломоносовский пр-т, д. 27, корп. 1

Anastasia A. Khozyaeva, Resident Physician, Department of Ophthalmology, Faculty of Fundamental Medicine

27 Lomonosovsky Ave., Bldg. 1, Moscow, 119991

hozaeva97@gmail.comhttps://orcid.org/0000-0002-5121-803XСтуловаА. Н.StulovaA. N.

Стулова Анна Николаевна, кандидат медицинских наук, ассистент кафедры офтальмологии факультета фундаментальной медицины 

119991, г. Москва, Ломоносовский пр-т, д. 27, корп. 1

Anna N. Stulova, Cand. Sci. (Med.), Assistant Professor, Department of Ophthalmology, Faculty of Fundamental Medicine

27 Lomonosovsky Ave., Bldg. 1, Moscow, 119991

https://orcid.org/0000-0002-7928-5410СеменоваН. С.SemenovaN. S.

Семенова Наталия Сергеевна, кандидат медицинских наук, доцент кафедры офтальмологии факультета фундаментальной медицины

119991, г. Москва, Ломоносовский пр-т, д. 27, корп. 1

Nataliya S. Semenova, Cand. Sci. (Med.), Associate Professor, Department of Ophthalmology, Faculty of Fundamental Medicine

27 Lomonosovsky Ave., Bldg. 1, Moscow, 119991

https://orcid.org/0000-0003-0481-3642АкопянВ. С.AkopyanV. S.

Акопян Владимир Сергеевич, доктор медицинских наук, профессор, заведующий кафедрой офтальмологии факультета фундаментальной медицины 

119991, г. Москва, Ломоносовский пр-т, д. 27, корп. 1

Vladimir S. Akopyan, Dr. Sci. (Med.), Professor, Head of the Department of Ophthalmology, Faculty of Fundamental Medicine

27 Lomonosovsky Ave., Bldg. 1, Moscow, 119991

ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияLomonosov Moscow State UniversityRussian Federation2026010420262814755Copyright © Академия медицинской оптики и оптометрии, 20262026Академия медицинской оптики и оптометрииАкадемия медицинской оптики и оптометрииhttps://www.theeyeglaz.com/jour/about/submissions#copyrightNoticehttps://www.theeyeglaz.com/jour/article/view/779

Актуальность. Оптическая когерентная томография является незаменимым диагностическим инструментом в офтальмологии, обеспечивающим высокоточную и неинвазивную визуализацию структурных характеристик хориоидеи in vivo. Благодаря развитию и совершенствованию методов визуализации описаны новые количественные и качественные показатели, которые вычисляются с помощью встроенного программного обеспечения томографов или рассчитываются с использованием дополнительных программ. В то же время остается актуальным вопрос унифицирования критериев оценки и систематизации существующих параметров, чтобы повысить их клиническую значимость и уровень достоверности научных данных. Настоящий обзор посвящен анализу возможностей оптической когерентной томографии в изучении хориоидеи. Цель: обобщить данные литературы о количественных икачественных показателях, характеризующих хориоидею, получаемых с помощью оптической когерентнойтомографии. Материалы и методы. Поиск литературы проводился в следующих базах данных: КиберЛенинка, eLIBRARY, PubMed, Embase, Google Scholar, ISI Web of Science, Medline в период с января по март 2025 г. Проанализировано 98 статей, в обзор включена 61 работа. В качестве источников изучались как клинические исследования, так и обзорные статьи на русском и английском языках. При поиске использовались такие ключевые слова: сосудистая оболочка, оптическая когерентная томография, субфовеальная толщина хориоидеи, карта толщины хориоидеи, картирование контура хориоидеи, индекс васкуляризации хориоидеи, карта васкулярности хориоидеи, объем хориоидеи, ImageJ. Результаты. Характеристики сосудистой оболочки, получаемые с помощью оптической когерентной томографии, включают в себя субфовеальную толщину хориоидеи, толщину хориоидеи в отдельных точках, индекс васкуляризации хориоидеи. Кроме того, программное обеспечение томографов последнего поколения дает возможность исследовать особенности сосудистой оболочки с помощью построения карт толщины, контура, васкулярности и объема хориоидеи. Подобный комплексный подход обеспечивает переход от точечных измерений к детальному трехмерному моделированию и функциональной оценке сосудистой оболочки. Заключение. Изучение новых структурных характеристик хориоидеи может способствовать расширению наших представлений о роли сосудистой оболочки в патогенезе заболеваний органа зрения.

Background. Optical coherence tomography is an indispensable diagnostic tool in ophthalmology, providing high-resolution, non-invasive in vivo visualization of choroidal structural characteristics. Advances in imaging technologies have enabled the identifi cation of new quantitative and qualitative parameters, either calculated by built-in tomograph software or derived using additional image-processing programs. At the same time, the need for unified assessment criteria and systematic classification of existing parameters remains relevant, as this would enhance their clinical applicability and improve the reliability of research data. This review analyzes the capabilities of optical coherence tomography in the evaluation of the choroid. Purpose: To summarize published data on quantitative and qualitative parameters characterizing the choroid as assessed by optical coherence tomography. Materials and methods. A literature search was conducted in the following databases: CyberLeninka, eLIBRARY. ru, PubMed, Embase, Google Scholar, Web of Science, and MEDLINE, covering the period from January to March 2025. A total of 98 publications were identifi ed, of which 61 were included in the review. Both clinical studies and review articles published in Russian and English over various time periods were analyzed. The search keywords included choroid, optical coherence tomography, subfoveal choroidal thickness, choroidal thickness map, choroidal contour mapping, choroidal vascularity index, choroidal vascularity map, choroidal volume, and ImageJ. Results. OCT-based assessment of the choroid includes measurement of subfoveal choroidal thickness, choroidal thickness at specific locations, and the choroidal vascularity index. In addition, next-generation optical coherence tomography software enables evaluation of choroidal features through choroidal thickness maps, choroidal contour mapping, choroidal vascularity maps, and choroidal volume analysis. This comprehensive approach allows a transition from point-based measurements to detailed three-dimensional modeling and functional assessment of the choroid. Conclusion. Investigation of novel structural characteristics of the choroid may contribute to a deeper understanding of the role of the choroid in the pathogenesis of ocular diseases.

хориоидеяоптическая когерентная томографиясубфовеальная толщина хориоидеииндекс васкуляризации хориоидеиImageJchoroidoptical coherence tomographysubfoveal choroidal thicknesschoroidal vascularity indexImageJавторы не получали финансирование при проведении исследования и написании статьи.The authors received no funding for the research or preparation of this article.ReferencesLinsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3117–3123.Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3117–3123.Sekiryu T. Choroidal imaging using optical coherence tomography: techniques and interpretations. Jpn J Ophthalmol. 2022;66(3):213–226. doi: 10.1007/s10384-022-00902-7Sekiryu T. Choroidal imaging using optical coherence tomography: techniques and interpretations. Jpn J Ophthalmol. 2022;66(3):213–226. doi: 10.1007/s10384-022-00902-7Jiang Z, Lin T, Lin A, Liu X, Mai X, Lin J, Cheung CYL, Chen H. Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography. Transl Vis Sci Technol. 2024;13(4):24. doi: 10.1167/tvst.13.4.24Jiang Z, Lin T, Lin A, Liu X, Mai X, Lin J, Cheung CYL, Chen H. Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography. Transl Vis Sci Technol. 2024;13(4):24. doi: 10.1167/tvst.13.4.24Chua J, Tan B, Wong D, Garhöfer G, Liew XW, Popa-Cherecheanu A, Loong Chin CW, Milea D, Li-Hsian Chen C, Schmetterer L. Optical coherence tomography angiography of the retina and choroid in systemic diseases. Prog Retin Eye Res. 2024;103:101292. doi: 10.1016/j.preteyeres.2024.101292Chua J, Tan B, Wong D, Garhöfer G, Liew XW, Popa-Cherecheanu A, Loong Chin CW, Milea D, Li-Hsian Chen C, Schmetterer L. Optical coherence tomography angiography of the retina and choroid in systemic diseases. Prog Retin Eye Res. 2024;103:101292. doi: 10.1016/j.preteyeres.2024.101292Selvam A, Driban M, Ong J, et al. Artificial intelligence in choroid through optical coherence tomography: a comprehensive review. ArtifIntell Rev 58, 109 (2025). doi: 10.1007/s10462-024-11067-9Selvam A, Driban M, Ong J, et al. Artifi cial intelligence in choroid through optical coherence tomography: a comprehensive review. Artif Intell Rev 58, 109 (2025). doi: 10.1007/s10462-024-11067-9Dohrmann GJ. The choroid plexus: a historical review. Brain Res. 1970;18(2):197–218. doi: 10.1016/0006-8993(70)90324-0Dohrmann GJ. The choroid plexus: a historical review. Brain Res. 1970;18(2):197–218. doi: 10.1016/0006-8993(70)90324-0Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29(2):144–168. doi: 10.1016/j.preteyeres.2009.12.002Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29(2):144–168. doi: 10.1016/j.preteyeres.2009.12.002Mundt GH, Hughes WF. Ultrasonics in ocular diagnosis. Am J Ophthalmol. 1956;41(3):488–498. doi: 10.1016/0002-9394(56)91262-4Mundt GH, Hughes WF. Ultrasonics in ocular diagnosis. Am J Ophthalmol. 1956;41(3):488–498. doi: 10.1016/0002-9394(56)91262-4Jalkh AE, Avila MP, Trempe CL, Schepens CL. Diffuse choroidal thickening detected by ultrasonography in various ocular disorders. Retina. 1983;3(4):277–83. doi: 10.1097/00006982-198300340-00009Jalkh AE, Avila MP, Trempe CL, Schepens CL. Diffuse choroidal thickening detected by ultrasonography in various ocular disorders. Retina. 1983;3(4):277–83. doi: 10.1097/00006982-198300340-00009Slakter JS, Yannuzzi LA, Guyer DR, Sorenson JA, Orlock DA. Indocyanine-green angiography. Curr Opin Ophthalmol. 1995;6(3):25–32. doi: 10.1097/00055735-199506000-00005Slakter JS, Yannuzzi LA, Guyer DR, Sorenson JA, Orlock DA. Indocyanine-green angiography. Curr Opin Ophthalmol. 1995;6(3):25–32. doi: 10.1097/00055735-199506000-00005Flower RW, Hochheimer BF. Clinical infrared absorption angiography of the choroid. American Journal of Ophthalmology. 1972;73(3):458–459. doi: 10.1016/0002-9394(72)90079-7Flower RW, Hochheimer BF. Clinical infrared absorption angiography of the choroid. American Journal of Ophthalmology. 1972;73(3):458–459. doi: 10.1016/0002-9394(72)90079-7Invernizzi A, Pellegrini M, Cornish E, Yi Chong Teo K, Cereda M, Chabblani J. Imaging the Choroid: From Indocyanine Green Angiography to Optical Coherence Tomography Angiography. Asia Pac J Ophthalmol (Phila). 2020;9(4):335–348. doi: 10.1097/APO.0000000000000307Invernizzi A, Pellegrini M, Cornish E, Yi Chong Teo K, Cereda M, Chabblani J. Imaging the Choroid: From Indocyanine Green Angiography to Optical Coherence Tomography Angiography. Asia Pac J Ophthalmol (Phila). 2020;9(4):335–348. doi: 10.1097/APO.0000000000000307Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27(1):45–88. doi: 10.1016/j.preteyeres.2007.07.005Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27(1):45–88. doi: 10.1016/j.preteyeres.2007.07.005Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146(4):496–500. doi: 10.1016/j.ajo.2008.05.032Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146(4):496–500. doi: 10.1016/j.ajo.2008.05.032Kishi S. Impact of swept source optical coherence tomography on ophthalmology. Taiwan J Ophthalmol. 2016;6(2):58–68. doi: 10.1016/j.tjo.2015.09.002Kishi S. Impact of swept source optical coherence tomography on ophthalmology. Taiwan J Ophthalmol. 2016;6(2):58–68. doi: 10.1016/j.tjo.2015.09.002Choudhry N, Duker JS, Freund KB, Kiss S, Querques G, Rosen R, Sarraf D, Souied EH, Stanga PE, Staurenghi G, Sadda SR. Classification and Guidelines for Widefield Imaging: Recommendations from the International Widefield Imaging Study Group. Ophthalmol Retina. 2019;3(10):843–849. doi: 10.1016/j.oret.2019.05.007Choudhry N, Duker JS, Freund KB, Kiss S, Querques G, Rosen R, Sarraf D, Souied EH, Stanga PE, Staurenghi G, Sadda SR. Classification and Guidelines for Widefield Imaging: Recommendations from the International Widefield Imaging Study Group. Ophthalmol Retina. 2019;3(10):843–849. doi: 10.1016/j.oret.2019.05.007Jia Y, Hormel TT, Hwang TS, Wu AL, Liang GB, Guo Y, Wei X, Ni S, Jian Y, Campbell JP, Bailey ST, Morrison JC, Huang D. Widefield OCT angiography. Prog Retin Eye Res. 2025;107:101378. doi: 10.1016/j.preteyeres.2025.101378Jia Y, Hormel TT, Hwang TS, Wu AL, Liang GB, Guo Y, Wei X, Ni S, Jian Y, Campbell JP, Bailey ST, Morrison JC, Huang D. Widefi eld OCT angiography. Prog Retin Eye Res. 2025;107:101378. doi: 10.1016/j.preteyeres.2025.101378Mrejen S, Spaide RF. Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol. 2013;58(5):387– 429. doi: 10.1016/j.survophthal.2012.12.001Mrejen S, Spaide RF. Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol. 2013;58(5):387– 429. doi: 10.1016/j.survophthal.2012.12.001Spaide RF. Choroidal Blood Flow: Review and Potential Explanation for the Choroidal Venous Anatomy Including the Vortex Vein System. Retina. 2020;40(10):1851–1864. doi: 10.1097/IAE.0000000000002931Spaide RF. Choroidal Blood Flow: Review and Potential Explanation for the Choroidal Venous Anatomy Including the Vortex Vein System. Retina. 2020;40(10):1851–1864. doi: 10.1097/IAE.0000000000002931Hayreh SS. Segmental nature of the choroidal vasculature. Br J Ophthalmol. 1975;59(11):631–648. doi: 10.1136/bjo.59.11.631Hayreh SS. Segmental nature of the choroidal vasculature. Br J Ophthalmol. 1975;59(11):631–648. doi: 10.1136/bjo.59.11.631Hayreh SS. In vivo choroidal circulation and its watershed zones. Eye (Lond). 1990;4(Pt 2):273–289. doi: 10.1038/eye.1990.39Hayreh SS. In vivo choroidal circulation and its watershed zones. Eye (Lond). 1990;4(Pt 2):273–289. doi: 10.1038/eye.1990.39Tan CS, Ouyang Y, Ruiz H, Sadda SR. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53(1):261–266. doi: 10.1167/iovs.11-8782Tan CS, Ouyang Y, Ruiz H, Sadda SR. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53(1):261–266. doi: 10.1167/iovs.11-8782Lee SW, Yu SY, Seo KH, Kim ES, Kwak HW. Diurnal variation in choroidal thickness in relation to sex, axial length, and baseline choroidal thickness in healthy Korean subjects. Retina. 2014;34(2):385–393. doi: 10.1097/IAE.0b013e3182993f29Lee SW, Yu SY, Seo KH, Kim ES, Kwak HW. Diurnal variation in choroidal thickness in relation to sex, axial length, and baseline choroidal thickness in healthy Korean subjects. Retina. 2014;34(2):385–393. doi: 10.1097/IAE.0b013e3182993f29Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N. Macular choroidal thickness and volume in normal subjects measured by sweptsource optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52(8):4971–4978. doi: 10.1167/iovs.11-7729Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N. Macular choroidal thickness and volume in normal subjects measured by sweptsource optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52(8):4971–4978. doi: 10.1167/iovs.11-7729Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci. 2010;51(4):2173–2176. doi: 10.1167/iovs.09-4383Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci. 2010;51(4):2173–2176. doi: 10.1167/iovs.09-4383Manjunath V, Taha M, Fujimoto JG, Duker JS. Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography. Am J Ophthalmol. 2010;150(3):325–329. doi: 10.1016/j.ajo.2010.04.018Manjunath V, Taha M, Fujimoto JG, Duker JS. Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography. Am J Ophthalmol. 2010;150(3):325–329. doi: 10.1016/j.ajo.2010.04.018Pang CE, Freund KB. Pachychoroid pigment epitheliopathy may masquerade as acute retinal pigment epitheliitis. Invest Ophthalmol Vis Sci. 2014;55(8):5252. doi: 10.1167/iovs.14-14959Pang CE, Freund KB. Pachychoroid pigment epitheliopathy may masquerade as acute retinal pigment epitheliitis. Invest Ophthalmol Vis Sci. 2014;55(8):5252. doi: 10.1167/iovs.14-14959Lehmann M, Bousquet E, Beydoun T, Behar-Cohen F. Pachychoroid: an inherited condition? Retina. 2015;35(1):10–16. doi: 10.1097/IAE.0000000000000287Lehmann M, Bousquet E, Beydoun T, Behar-Cohen F. Pachychoroid: an inherited condition? Retina. 2015;35(1):10–16. doi: 10.1097/IAE.0000000000000287Jonas J, Forster T, Steinmetz P, Schlichtenbrede F, Harder B. Choroidal thickness in age-related macular degeneration. Retina. 2014;346:1149–1155. doi: 10.1097/IAE.0000000000000035Jonas J, Forster T, Steinmetz P, Schlichtenbrede F, Harder B. Choroidal thickness in age-related macular degeneration. Retina. 2014;346:1149–1155. doi: 10.1097/IAE.0000000000000035Kumar J, Wai K, Ehlers J, Singh R, Rachitskaya A. Subfoveal choroidal thickness as a prognostic factor in exudative age-related macular degeneration. Br J Ophthalmol. 2019;103(7):918– 921. doi: 10.1136/bjophthalmol-2018-312625Kumar J, Wai K, Ehlers J, Singh R, Rachitskaya A. Subfoveal choroidal thickness as a prognostic factor in exudative age-related macular degeneration. Br J Ophthalmol. 2019;103(7):918– 921. doi: 10.1136/bjophthalmol-2018-312625Beraldo DP, Rezende MP, Alexander JG, Polido J, Belfort R Jr, Cabral T. Correlations between subfoveal choroidal thickness, macular thickness, and visual outcome in neovascular age-related macular degeneration using swept source OCT: insights from intravitreal afl ibercept treatment. Int J Retina Vitreous. 2023;9(1):70. doi: 10.1186/s40942-023-00506-4Beraldo DP, Rezende MP, Alexander JG, Polido J, Belfort R Jr, Cabral T. Correlations between subfoveal choroidal thickness, macular thickness, and visual outcome in neovascular age-related macular degeneration using swept source OCT: insights from intravitreal afl ibercept treatment. Int J Retina Vitreous. 2023;9(1):70. doi: 10.1186/s40942-023-00506-4Тарутта ЕП, Милаш СВ, Епишина МВ, Елисеева ЕК. Изменение толщины хориоидеи у детей с миопией на фоне ношения бифокальных мягких контактных линз. Вестник офтальмологии. 2022;138(2):16–22.Tarutta EP, Milash SV, Epishina MV, Eliseeva EK. Changes in subfoveal choroidal thickness in myopic children who wear bifocal soft contact lenses. Russian Annals of Ophthalmology. 2022;138(2):16–22. (In Russ.) doi: 10.17116/oftalma202213802116Chhablani J, Rao PS, Venkata A, Rao HL, Rao BS, Kumar U, Narayanan R, Pappuru RR. Choroidal thickness profi le in healthy Indian subjects. Indian J Ophthalmol. 2014;62(11):1060–1063. doi: 10.4103/0301-4738.146711Chhablani J, Rao PS, Venkata A, Rao HL, Rao BS, Kumar U, Narayanan R, Pappuru RR. Choroidal thickness profile in healthy Indian subjects. Indian J Ophthalmol. 2014;62(11):1060–1063. doi: 10.4103/0301-4738.146711Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009;147(5):811–815. doi: 10.1016/j.ajo.2008.12.008Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009;147(5):811–815. doi: 10.1016/j.ajo.2008.12.008Lee CO, Zhang X, Yuan N, et al. Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children. Sci Rep. 2021;11(1):13749. doi:10.1038/s41598-021-92980-9Lee CO, Zhang X, Yuan N, et al. Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children. Sci Rep. 2021;11(1):13749. doi:10.1038/s41598-021-92980-9Xie R, Qiu B, Chhablani J, Zhang X. Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review. Front Med (Lausanne). 2021;8:783519. doi:10.3389/fmed.2021.783519Xie R, Qiu B, Chhablani J, Zhang X. Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review. Front Med (Lausanne). 2021;8:783519. doi:10.3389/fmed.2021.783519El-Shazly AA, Farweez YA, Elsebaay ME, El-Zawahry WMA. Correlation between choroidal thickness and degree of myopia assessed with enhanced depth imaging optical coherence tomography. Eur. J. Ophthalmol. 2017;27:577–584. doi: 10.5301/ejo.5000936El-Shazly AA, Farweez YA, Elsebaay ME, El-Zawahry WMA. Correlation between choroidal thickness and degree of myopia assessed with enhanced depth imaging optical coherence tomography. Eur. J. Ophthalmol. 2017;27:577–584. doi: 10.5301/ejo.5000936Xiong S, He X, Zhang B, Deng J, Wang J, Lv M, Zhu J, Zou H, Xu X. Changes in Choroidal Thickness Varied by Age and Refraction in Children and Adolescents: A 1-Year Longitudinal Study. Am. J. Ophthalmol. 2020;213:46–56. doi: 10.1016/j.ajo.2020.01.003Xiong S, He X, Zhang B, Deng J, Wang J, Lv M, Zhu J, Zou H, Xu X. Changes in Choroidal Thickness Varied by Age and Refraction in Children and Adolescents: A 1-Year Longitudinal Study. Am. J. Ophthalmol. 2020;213:46–56. doi: 10.1016/j.ajo.2020.01.003Muhiddin HS, Mayasari AR, Umar BT, Sirajuddin J, Patellongi I, Islam IC, Ichsan AM. Choroidal Thickness in Correlation with Axial Length and Myopia Degree. Vision (Basel). 2022;6(1):16. doi:10.3390/vision6010016Muhiddin HS, Mayasari AR, Umar BT, Sirajuddin J, Patellongi I, Islam IC, Ichsan AM. Choroidal Thickness in Correlation with Axial Length and Myopia Degree. Vision (Basel). 2022;6(1):16. doi:10.3390/vision6010016Shin JW, Shin YU, Lee BR. Choroidal thickness and volume mapping by a six radial scan protocol on spectral-domain optical coherence tomography. Ophthalmology. 2012;119(5):1017–1023. doi: 10.1016/j.ophtha.2011.10.029Shin JW, Shin YU, Lee BR. Choroidal thickness and volume mapping by a six radial scan protocol on spectral-domain optical coherence tomography. Ophthalmology. 2012;119(5):1017–1023. doi: 10.1016/j.ophtha.2011.10.029Breher K, Ohlendorf A, Wahl S. A metrological approach to the analysis of choroidal thickness by optical coherence tomography 3D scans in myopia research. Sci Rep. 2019;9(1):20322. doi: 10.1038/s41598-019-56915-9Breher K, Ohlendorf A, Wahl S. A metrological approach to the analysis of choroidal thickness by optical coherence tomography 3D scans in myopia research. Sci Rep. 2019;9(1):20322. doi: 10.1038/s41598-019-56915-9Dansingani KK, Balaratnasingam C, Naysan J, Freund KB. En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina. 2016;36(3):499–516. doi: 10.1097/IAE.0000000000000742Dansingani KK, Balaratnasingam C, Naysan J, Freund KB. En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina. 2016;36(3):499–516. doi: 10.1097/IAE.0000000000000742Phasukkijwatana N, Freund KB, Dolz-Marco R, Al-Sheikh M, Keane PA, Egan CA, et al. Peripapillary pachychoroid syndrome. Retina. 2018;38(9):1652–1667. doi: 10.1097/IAE.0000000000001907Phasukkijwatana N, Freund KB, Dolz-Marco R, Al-Sheikh M, Keane PA, Egan CA, et al. Peripapillary pachychoroid syndrome. Retina. 2018;38(9):1652–1667. doi: 10.1097/IAE.0000000000001907Arora S, Singh SR, Rosario B, Ibrahim MN, Selvam A, Zarnegar A, Harihar S, Sant V, Sahel JA, Vupparaboina KK, Chhablani J. Three-dimensional choroidal contour mapping in healthy population. Sci Rep. 2024;14(1):6210. doi: 10.1038/s41598-024-56376-9Arora S, Singh SR, Rosario B, Ibrahim MN, Selvam A, Zarnegar A, Harihar S, Sant V, Sahel JA, Vupparaboina KK, Chhablani J. Three-dimensional choroidal contour mapping in healthy population. Sci Rep. 2024;14(1):6210. doi: 10.1038/s41598-024-56376-9Arora S, Singh SR, Vupparaboina SC, Rosario B, Ibrahim MN, Selvam A, Zarnegar A, Harihar S, Sant V, Sahel JA, Vupparaboina KK, Chhablani J. Three-Dimensional Choroidal Contour Mapping in Healthy and Diseased Eyes. Transl Vis Sci Technol. 2025;14(6):16. doi: 10.1167/tvst.14.6.16Arora S, Singh SR, Vupparaboina SC, Rosario B, Ibrahim MN, Selvam A, Zarnegar A, Harihar S, Sant V, Sahel JA, Vupparaboina KK, Chhablani J. Three-Dimensional Choroidal Contour Mapping in Healthy and Diseased Eyes. Transl Vis Sci Technol. 2025;14(6):16. doi: 10.1167/tvst.14.6.16Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY. Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep. 2016;6:21090. doi: 10.1038/srep21090Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY. Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep. 2016;6:21090. doi: 10.1038/srep21090Sonoda S, Sakamoto T, Yamashita T, Uchino E, Kawano H, Yoshihara N, Terasaki H, Shirasawa M, Tomita M, Ishibashi T. Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images. Am J Ophthalmol. 2015;159(6):1123–1131. doi: 10.1016/j.ajo.2015.03.005Sonoda S, Sakamoto T, Yamashita T, Uchino E, Kawano H, Yoshihara N, Terasaki H, Shirasawa M, Tomita M, Ishibashi T. Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images. Am J Ophthalmol. 2015;159(6):1123–1131. doi: 10.1016/j.ajo.2015.03.005Xuan M, Li C, Kong X, Zhang J, Wang W, He M. Distribution and determinants of choroidal vascularity index in healthy eyes from deep-learning choroidal analysis: a population-based SS-OCT study. Br J Ophthalmol. 2024;108(4):546–551. doi: 10.1136/bjo-2023-323224Xuan M, Li C, Kong X, Zhang J, Wang W, He M. Distribution and determinants of choroidal vascularity index in healthy eyes from deep-learning choroidal analysis: a population-based SS-OCT study. Br J Ophthalmol. 2024;108(4):546–551. doi: 10.1136/bjo-2023-323224Valsecchi N, Sadeghi E, Davis E, Ibrahim MN, Hasan N, Bollepalli SC, Singh SR, Fontana L, Sahel JA, Vupparaboina KK, Chhablani J. Assessment of choroidal vessels in healthy eyes using 3-dimensional vascular maps and a semi-automated deep learning approach. Sci Rep. 2025;15(1):714. doi: 10.1038/s41598-025-85189-7Valsecchi N, Sadeghi E, Davis E, Ibrahim MN, Hasan N, Bollepalli SC, Singh SR, Fontana L, Sahel JA, Vupparaboina KK, Chhablani J. Assessment of choroidal vessels in healthy eyes using 3-dimensional vascular maps and a semi-automated deep learning approach. Sci Rep. 2025;15(1):714. doi: 10.1038/s41598-025-85189-7Tan KA, Laude A, Yip V, Loo E, Wong EP, Agrawal R. Choroidal vascularity index– A novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol. 2016;94(7):e612–616.Tan KA, Laude A, Yip V, Loo E, Wong EP, Agrawal R. Choroidal vascularity index– A novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol. 2016;94(7):e612–616.Kim M, Ha MJ, Choi SY, Park Y-H. Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep. 2018;8(1):70.Kim M, Ha MJ, Choi SY, Park Y-H. Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep. 2018;8(1):70.Obadă O, Pantalon AD, Rusu-Zota G, Hăisan A, Lupuşoru SI, Chiseliţă D. Choroidal assessment in patients with type 2 diabetes mellitus and non-proliferative diabetic retinopathy by swept-source ocular coherence tomography and image binarization. Medicina. 2022;58(7):918.Obadă O, Pantalon AD, Rusu-Zota G, Hăisan A, Lupuşoru SI, Chiseliţă D. Choroidal assessment in patients with type 2 diabetes mellitus and non-proliferative diabetic retinopathy by swept-source ocular coherence tomography and image binarization. Medicina. 2022;58(7):918.Kim JT, Lee IG. Correlation of renal profiles with choroidal vascularity index in eyes with diabetic retinopathy. J Clin Med. 2021;10(21):5155.Kim JT, Lee IG. Correlation of renal profi les with choroidal vascularity index in eyes with diabetic retinopathy. J Clin Med. 2021;10(21):5155.Zhang Y, Yang L, Gao Y, Zhang D, Tao Y, Xu H, et al. Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study. Alzheimer’s Res Ther. 2022;14(1):116.Zhang Y, Yang L, Gao Y, Zhang D, Tao Y, Xu H, et al. Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study. Alzheimer’s Res Ther. 2022;14(1):116.Singh SR, Rasheed MA, Parveen N, Goud A, Ankireddy S, Sahoo NK, Vupparaboina KK, Jana S, Chhablani J. En-face choroidal vascularity map of the macula in healthy eyes. Eur J Ophthalmol. 2021;31(1):218–225. doi: 10.1177/1120672119883593Singh SR, Rasheed MA, Parveen N, Goud A, Ankireddy S, Sahoo NK, Vupparaboina KK, Jana S, Chhablani J. En-face choroidal vascularity map of the macula in healthy eyes. Eur J Ophthalmol. 2021;31(1):218–225. doi: 10.1177/1120672119883593Sahoo NK, Singh SR, Beale O, Nkrumah G, Rasheed MA, Jabeen A, Vupparaboina KK, Ibrahim MN, Tatti F, Chandra K, Lanza M, Iovino C, Peiretti E, Chhablani J. Choroidal Vascularity Map in Unilateral Central Serous Chorioretinopathy: A Comparison with Fellow and Healthy Eyes. Diagnostics (Basel). 2021;11(5):861. doi: 10.3390/diagnostics11050861Sahoo NK, Singh SR, Beale O, Nkrumah G, Rasheed MA, Jabeen A, Vupparaboina KK, Ibrahim MN, Tatti F, Chandra K, Lanza M, Iovino C, Peiretti E, Chhablani J. Choroidal Vascularity Map in Unilateral Central Serous Chorioretinopathy: A Comparison with Fellow and Healthy Eyes. Diagnostics (Basel). 2021;11(5):861. doi: 10.3390/diagnostics11050861Goud A, Singh SR, Sahoo NK, Rasheed MA, Vupparaboina KK, Ankireddy S, Lupidi M, Chhablani J. New Insights on Choroidal Vascularity: A Comprehensive Topographic Approach. Invest Ophthalmol Vis Sci. 2019;60(10):3563–3569. doi: 10.1167/iovs.18-26381Goud A, Singh SR, Sahoo NK, Rasheed MA, Vupparaboina KK, Ankireddy S, Lupidi M, Chhablani J. New Insights on Choroidal Vascularity: A Comprehensive Topographic Approach. Invest Ophthalmol Vis Sci. 2019;60(10):3563–3569. doi: 10.1167/iovs.18-26381Singh SR, Invernizzi A, Rasheed MA, Cagini C, Goud A, Vupparaboina KK, Cozzi M, Lupidi M, Chhablani J. Wide-field Choroidal Vascularity in Healthy Eyes. Am J Ophthalmol. 2018;193:100–105. doi: 10.1016/j.ajo.2018.06.016Singh SR, Invernizzi A, Rasheed MA, Cagini C, Goud A, Vupparaboina KK, Cozzi M, Lupidi M, Chhablani J. Wide-field Choroidal Vascularity in Healthy Eyes. Am J Ophthalmol. 2018;193:100–105. doi: 10.1016/j.ajo.2018.06.016Sato-Akushichi M, Ono S, Klose G, Song Y. Choroidal Volume Evaluation after Photodynamic Therapy Using New Optical Coherence Tomography Imaging Algorithm. Pharmaceuticals (Basel). 2021 Nov 10;14(11):1140. doi: 10.3390/ph14111140. Erratum in: Pharmaceuticals (Basel). 2022;15(3):349. doi: 10.3390/ph15030349Sato-Akushichi M, Ono S, Klose G, Song Y. Choroidal Volume Evaluation after Photodynamic Therapy Using New Optical Coherence Tomography Imaging Algorithm. Pharmaceuticals (Basel). 2021 Nov 10;14(11):1140. doi: 10.3390/ph14111140. Erratum in: Pharmaceuticals (Basel). 2022;15(3):349. doi: 10.3390/ph15030349Hwang S, Kang M, Ham DI, Kong M. Genetic Influence on Choroidal Volume. Am J Ophthalmol. 2021;224:143–149. doi: 10.1016/j.ajo.2020.12.008Hwang S, Kang M, Ham DI, Kong M. Genetic Infl uence on Choroidal Volume. Am J Ophthalmol. 2021;224:143–149. doi: 10.1016/j.ajo.2020.12.008Barteselli G, Chhablani J, El-Emam S, Wang H, Chuang J, Kozak I, Cheng L, Bartsch DU, Freeman WR. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology. 2012;119(12):2572–2578. doi: 10.1016/j.ophtha.2012.06.065Barteselli G, Chhablani J, El-Emam S, Wang H, Chuang J, Kozak I, Cheng L, Bartsch DU, Freeman WR. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology. 2012;119(12):2572–2578. doi: 10.1016/j.ophtha.2012.06.065

The authors declare that there are no conflicts of interest present.